AN IMPROVED PROCESS FOR THE PREPARATION OF TEMOZOLOMIDE AND ANALOGS

The present invention relates to a process for isolating temozolomide from an acidic solution containing temozolomide comprising; subjecting the acidic solution of temozolomide to a counter-current continuous liquid-liquid extraction using water immiscible solvent. The present invention also relates...

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Bibliographische Detailangaben
Hauptverfasser:	RAO DHARMARAJ RAMACHANDRA, KANKAN RAJENDRA NARAYANRAO, SRINIVAS PATHI L
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a process for isolating temozolomide from an acidic solution containing temozolomide comprising; subjecting the acidic solution of temozolomide to a counter-current continuous liquid-liquid extraction using water immiscible solvent. The present invention also relates to a process for purifying temozolomide comprising refluxing temozolomide in an acetone-water mixture having a pH from 2.5 to 4.5 followed by recovering purified temozolomide.