SELF-PRESERVED AQUEOUS PHARMACEUTICAL COMPOSITIONS

The use of a borate/polyol and zinc system to enhance the antimicrobial activity of multi-dose pharmaceutical compositions is described. The compositions do not require a conventional anti-microbial preservative and therefore are referred to as being self-preserved. The compositions possess sufficie...

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Bibliographische Detailangaben
Hauptverfasser: KEITH, David, J, CHOWHAN, Masood A
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The use of a borate/polyol and zinc system to enhance the antimicrobial activity of multi-dose pharmaceutical compositions is described. The compositions do not require a conventional anti-microbial preservative and therefore are referred to as being self-preserved. The compositions possess sufficient antimicrobial activity to satisfy the preservative efficacy requirements of the USP for aqueous ophthalmic compositions.