Demethylation of 14-hydroxy substituted alkaloid derivatives

Demethylation of 14-hydroxy substituted alkaloid derivatives

The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R 1 OOC-N=N-COOR 2 in a suitabl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BERTOGG, ANDREAS, DINKEL, THOMAS, LAUTERBACH, ERIK HEINZ, HELLER, SABRINA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R 1 OOC-N=N-COOR 2 in a suitable solvent.