Process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines and their optical stereoisomers

Process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines and their optical stereoisomers

The invention provides a process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines via novel semiester derivatives containing o-carboxy benzoyl group as intermediates. The 3-hydroxy-3-arylpropylamines serve as precursor for the preparation of serotonin or noradrenalin reuptak...

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Bibliographische Detailangaben
Hauptverfasser: KORIKANA, SIVA, PRASAD, MODI, INDRAVADAN, AMBALAL, PONNAIAH, RAVI, SHUKLA, MANISH, CHANDRAKANT, KAGATHARA, NIRAV, KESHAVLAL, JAIN, PRATIMA, KHAMAR, BAKULESH, MAFATLAL, TARANNUM
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention provides a process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines via novel semiester derivatives containing o-carboxy benzoyl group as intermediates. The 3-hydroxy-3-arylpropylamines serve as precursor for the preparation of serotonin or noradrenalin reuptake inhibitors such as duloxetine, atomoxetine, fluoxetine, nisoxetine and norfluoxetine.