PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL FORM I

PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL FORM I

The present invention provides an improved process for the manufacture of candesartan cilexetil form I. Further disclosed is a candesartan cilexetil preparation containing less than 0.15%, preferably less than 0.10%, of (+-)-1 -Hydroxyethyl candesartan oxanyl carbonate (ester) of the following formu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SOSTARIC-VIRC, NIVES, BENKIC, PRIMOZ, SMRKOLJ, POLONA, SENICAR, SUZANA, HVALA, JERNEJ, ZUPANCIC, SILVO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides an improved process for the manufacture of candesartan cilexetil form I. Further disclosed is a candesartan cilexetil preparation containing less than 0.15%, preferably less than 0.10%, of (+-)-1 -Hydroxyethyl candesartan oxanyl carbonate (ester) of the following formula (V) wherein one of A, B and C is an oxygen atom and the other two are -CH2- groups.