COMPOUND THAT CAN INHIBIT UBC13-UEV INTERACTIONS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC USES

The invention relates to a compound (I) wherein R is a heterocyclyl radical; R 1 and R 2 are independently H or alkyl; R 3 is H, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl; R 4 and R 5 are independently H or alkyl; q is a number selected from 0 an...

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Bibliographische Detailangaben
Hauptverfasser:	THOMSON OKATSU, TIMOTHY, GONZÁLEZ RUIZ, DOMINGO, MESSEGUER PEYPOCH, ÁNGEL, SANCLIMENS PÉREZ DE ROZAS, GLORIA, MASIP MASIP, ISABEL, MORREALE DE LEÓN, ANTONIO, SCHEPER SIGMUND, JOHANNA, MOURE FERNÁNDEZ, ALEJANDRA, RAMÍREZ ORTIZ, ÁNGEL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a compound (I) wherein R is a heterocyclyl radical; R 1 and R 2 are independently H or alkyl; R 3 is H, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl; R 4 and R 5 are independently H or alkyl; q is a number selected from 0 and 1; and the salts, solvates, prodrugs or stereoisomers thereof having inhibitory activity for UBC13-UEV interactions and which can be used in the production of pharmaceutical compositions intended for antitumor therapy or the treatment and/or prophylaxis of diseases associated to metabolic pathways involving the UBC13 enzyme, metabolic pathways involving transcriptional factor NF-ºB, or pathways involving PCNA or RAD6. R- (CR 1 R 2 ) q-CO-N (R 3 )-C(R 4 R 5 )-CO-NH 2 (I)