IMPROVED OXIDATION PROCESS WITH ENHANCED SAFETY USEFUL IN THE MANUFACTURE OF MOXIDECTIN BY MEANS OF STABILISED 2-IODOXYBENZOIC ACID (SIBX)

IMPROVED OXIDATION PROCESS WITH ENHANCED SAFETY USEFUL IN THE MANUFACTURE OF MOXIDECTIN BY MEANS OF STABILISED 2-IODOXYBENZOIC ACID (SIBX)

The present invention provides a safe and effective process for the selective oxidation of a 5-O-protected-LLF-28249-alpha compound to the corresponding 23-keto compound of formula I wherein R is a protecting group. The present invention also provides the use of the selective oxidation process in th...

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Bibliographische Detailangaben
Hauptverfasser: MASSARA, PASQUALE, SAPIENZA, STEFANIA, MIRAGLIA, GIUSEPPE, PATEL, JIGNESH, CARACO, MARCO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides a safe and effective process for the selective oxidation of a 5-O-protected-LLF-28249-alpha compound to the corresponding 23-keto compound of formula I wherein R is a protecting group. The present invention also provides the use of the selective oxidation process in the manufacture of moxidectin.