KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex wit...

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Bibliographische Detailangaben
Hauptverfasser: SEXTON, DANIEL J, LADNER, ROBERT C, NUNN, ADRIAN D, NANJAPPAN, PALANIAPPA, VON WRONSKI, MATHEW A, POCHON, SIBYLLE, SHRIVASTAVA, AJAY, SONG, BO, PILLAI, RADHAKRISHNA, MARINELLI, EDMUND R, DRANSFIELD, DANIEL T, RAMALINGAM, KONDAREDDIAR, FAN, HONG, YAN, FENG, LINDER, KAREN E, SWENSON, ROLF E, ARBOGAST, CHRISTOPHE, BUSSAT, PHILIPPE, SATO, AARON K
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e.g ., having a K D < 1 µM).