STATIONARY PHASE AND COLUMN USING CUCURBITURIL BONDED SILICA GEL, AND SEPARATION METHOD OF TAXOL USING THE COLUMN

Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound sili...

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Bibliographische Detailangaben
Hauptverfasser: KO, YOUNG-HO, KIM, KIMOON, SELVAPALAM, NARAYANAN, NAGARAJAN, ERUMAIPATTY, R, PARK, KYENG-MIN
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.