METHOD OF INDUCING NUCLEATION OF A MATERIAL

Methods of inducing nucleation of a material is provided. The disclosed methods comprise the steps of bringing the material to a temperature near or below a phase transition temperature and altering the pressure to induce nucleation of the material. The disclosed methods are useful in freeze-drying...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SEVER, ROBERT, REX, GRINTER, NIGEL, VERDONE, MELINDA, LEE, GASTEYER, THEODORE, HALL, III, HUNEK, BALAZS
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:Methods of inducing nucleation of a material is provided. The disclosed methods comprise the steps of bringing the material to a temperature near or below a phase transition temperature and altering the pressure to induce nucleation of the material. The disclosed methods are useful in freeze-drying processes, particularly pharmaceutical freeze-drying processes.