THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS

THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS

The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.

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Bibliographische Detailangaben
Hauptverfasser: WOHLHIETER, GEORGE E, WANG, XIANGHONG, HAN, NIANHE, HUANG, XIN, RIDER, JAMES T, LIU, QINGYIAN, VISWANADHAN, VELLARKAD N, LI, AIWEN, LEE, MATTHEW R, FOTSCH, CHRISTOPHER H, YUAN, CHESTER CHENGUANG, ZENG, QINGPING, WEILER, KURT E, YAO, GUOMIN, BOURBEAU, MATTHEW P, DOMINGUEZ, CELIA, TASKER, ANDREW S, ALLEN, JOHN G, TADESSE, SEIFU, HONG, FANG-TSAO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.