Method of analyzing optical purity of 1-Chloro-3, 5-Ditoluyl-2-Deoxy-L-Ribose using (S)-Tetrahydro-3-Furanol

A method of analyzing the optical purity of 1-chloro-3,5-ditoluyl-2-deoxy-L-ribose represented by the following formula 1 is disclosed, The analysis method includes: allowing 1-chloro-3,5-ditoluyl-2-deoxy-L-ribose of the following formula 1 to react with (S)-tetrahydro-3-furanol of the following for...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, YONG, TAE, KIM, KYUNG II, JEON, JAE, HOON, KWON, SOON, JEONG, YUN, JI SUK, HA, SEUNG BUM
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PHYSICS SUGARS TESTING
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Beschreibung
Zusammenfassung:	A method of analyzing the optical purity of 1-chloro-3,5-ditoluyl-2-deoxy-L-ribose represented by the following formula 1 is disclosed, The analysis method includes: allowing 1-chloro-3,5-ditoluyl-2-deoxy-L-ribose of the following formula 1 to react with (S)-tetrahydro-3-furanol of the following formula 2 so as to prepare 1-[(S)-tetrahydro-3-furanol]-3,5-ditoluyl-2-deoxy-L-ribose of the following formula 3; analyzing the compound of formula 3 using chiral HPLC; and calculating the content of diastereomer 1-[(S)-tetrahydro-3-furanol]-3,5-ditoluyl-2-deoxy-D-ribose of the following formula 4 in the compound of formula 3 on the basis of the area ratio of separated peaks on the HPLC chromatogram; and