NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS

NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS

Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provide...

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Bibliographische Detailangaben
Hauptverfasser: SIDDIQUI, M. ARSHAD, HRUZA, ALAN, W, MAYHOOD, TODD, W, SHIPPS, GERALD W., JR, LEES, EMMA, M, POPOVICI-MULLER, JANETA, MCNEMAR, CHARLES, WAYNE, ZHAO, LIANYUN, MADISON, VINCENT, S, FISCHMANN, THIERRY, O, WINDSOR, WILLIAM, T, PARRY, DAVID, A, DUCA, JOSE, S, DENG, YONGQI, CURRAN, PATRICK, J, ZHANG, RUMIN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.