Pleuromutilin derivatives as antimicrobials

Derivatives of pleuromutilin in which the glycolic ester moiety at position 14 is replaced by R 2 (CH 2 ) m X(CH 2 ) n CH 2 COO are of use in antimicrobial therapy. In which: each of n and m is independently 0, 1 or 2; X is selected from -O-, -S-, -S(O)-, -SO 2 -, -CO.O-, -NH-, -CONH-, -NHCONH- and...

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Bibliographische Detailangaben
Hauptverfasser:	SANDERSON, FRANCIS, DOMINIC, DABBS, STEPHEN, HUNT, ERIC, WOODNUTT, GARY, BERRY, VALERIE, FRYDRYCH, COLIN, HENRY
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Derivatives of pleuromutilin in which the glycolic ester moiety at position 14 is replaced by R 2 (CH 2 ) m X(CH 2 ) n CH 2 COO are of use in antimicrobial therapy. In which: each of n and m is independently 0, 1 or 2; X is selected from -O-, -S-, -S(O)-, -SO 2 -, -CO.O-, -NH-, -CONH-, -NHCONH- and a bond;R 1 is vinyl or ethyl;R 2 is a non-aromatic monocyclic or bicyclic group containing one or two basic nitrogen atoms and attached through a ring carbon atom; R 3 is H or OH; or the moiety R 2 (CH 2 ) m X(CH 2 ) n CH 2 COO at position 14 of (IA) or (IB) is replaced by R a R b C=CHCOO in which one of R a and R b is hydrogen and the other is R 2 or R a and R b together form R 2 ; or a pharmaceutically acceptable salt thereof