DIPIPERAZINYL KETONES AND RELATED ANALOGUES

DIPIPERAZINYL KETONES AND RELATED ANALOGUES

Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, dom...

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Bibliographische Detailangaben
Hauptverfasser: XU, YUELIAN, PETERSON, JOHN M, GE, PING, OCHTERSKI, JOSEPH W, HAN, BINGSONG, OHLIGER, ROBERT, CALDWELL, TIMOTHY M, GAO, YANG, XIE, LINGHONG
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).