Methods of selecting cell clones

The invention describes novel methods for selecting cell clones which produce high amounts of protein of interest. In one method the amount of protein is measured before the cells are passaged for the first time. In another method a high throughput automated platform is used under sterile environmen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KAUFMANN, HITTO, FIEDER, JUERGEN
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The invention describes novel methods for selecting cell clones which produce high amounts of protein of interest. In one method the amount of protein is measured before the cells are passaged for the first time. In another method a high throughput automated platform is used under sterile environment conditions with class A particle load of less than 100 particles per m3.