A CRYSTAL STRUCTURE AND USES THEREOF

The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and scree...

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Bibliographische Detailangaben
Hauptverfasser:	ROSSJOHN, JAMIE, LUCET, ISABELLE, STYLES, MICHELLE, LEANNE, WILKS, ANDREW, FREDERICK, FANTINO, EMMANUELLE, BURNS, CHRISTOPHER, JOHN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CALCULATING CHEMISTRY COMPUTING COUNTING DATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FORADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORYOR FORECASTING PURPOSES IMAGE DATA PROCESSING OR GENERATION, IN GENERAL METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE,COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTINGPURPOSES, NOT OTHERWISE PROVIDED FOR
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Beschreibung
Zusammenfassung:	The present invention relates to X-ray crystallography studies of a JAK2 kinase domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.