Inhibitors of cytosolic phospholipase A2

Inhibitors of cytosolic phospholipase A2

This invention provides substituted indole compounds of the general formula: (I) and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatmen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: THAKKER, PARESH, TAM, STEVE, YIK-KAI, CHEN, LIHREN, MCKEW, JOHN, CAEDMON, SUM, FUK-WAH, LEE, KATHERINE, LIN, BEHNKE, MARK, LEO, CLARK, JAMES, DONALD, HU, BAIHUA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention provides substituted indole compounds of the general formula: (I) and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.