DNA-PK INHIBITORS

DNA-PK INHIBITORS

Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C( O), CH2 and NH are disclosed for use in...

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Bibliographische Detailangaben
Hauptverfasser: NEWELL, D.R, CALVERT, H.A, GRIFFIN, R.J, MENEAR, KEITH ALLAN, HUMMERSONE, MARC G, HARDCASTLE, I.R, COCKCROFT, XIAO-LING F, GOLDING, B.T, CURTIN, N.J, FRIGERIO, MARK, DESAGE-EL MURR, MARINE, MARTIN, NIALL MORRISON BARR, SARAVANAN, KAPPUSAMY, SMITH, GRAEME CAMERON MURRAY
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C( O), CH2 and NH are disclosed for use in inhibiting DNA-PK.