[1,2,4]-DITHIAZOLI(DI)NE DERIVATIVES, INDUCERS OF GLUTHATHIONE-S-TRANSFERASE AND NADPH QUINONE OXIDO-REDUCTASE, FOR PROPHYLAXIS AND TREATMENT OF ADVERSE CONDITIONS ASSOCIATED WITH CYTOTOXICITY IN GENERAL AND APOPTOSIS IN PARTICULAR

[1,2,4]-DITHIAZOLI(DI)NE DERIVATIVES, INDUCERS OF GLUTHATHIONE-S-TRANSFERASE AND NADPH QUINONE OXIDO-REDUCTASE, FOR PROPHYLAXIS AND TREATMENT OF ADVERSE CONDITIONS ASSOCIATED WITH CYTOTOXICITY IN GENERAL AND APOPTOSIS IN PARTICULAR

The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediate...

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Bibliographische Detailangaben
Hauptverfasser: PRAS-RAVES, MARIA L, KEIZER, HISKIAS G, VAN VLIET, BERNARD J, VAN SCHARRENBURG, GUSTAAF J, FEENSTRA, ROELOF W
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.