AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS

The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit beta-secretase (BACE) and treat beta-amyloid deposits and neurofibrillary tangles.

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Bibliographische Detailangaben
Hauptverfasser:	LOVERING, FRANK ELDRIDGE, ELLINGBOE, JOHN WATSON, MOORE, WILLIAM JAY, STOCK, JOSEPH RAYMOND, MORRIS, KOI MICHELE, MANAS, ERIC STEVEN, ZHOU, PING, COLE, DEREK CECIL, CONDON, JEFFREY SCOTT, JENNINGS, LEE DALTON, SUKHDEO, MOHANI NIRMALA, WU, JUNJUN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit beta-secretase (BACE) and treat beta-amyloid deposits and neurofibrillary tangles.