PREPARATION OF CRUDE CANDESARTAN CILEXETIL

PREPARATION OF CRUDE CANDESARTAN CILEXETIL

A process for preparing candesartan cilexetil comprising heating a solution of trityl candesartan cilexetil in a water immiscible solvent in the presence of at least one C1-C4 alcohol and a first portion of water; combining the solution with a second portion of water to obtain a two-phase system; an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MALACHI, OMER, KURGAN, ZIV
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for preparing candesartan cilexetil comprising heating a solution of trityl candesartan cilexetil in a water immiscible solvent in the presence of at least one C1-C4 alcohol and a first portion of water; combining the solution with a second portion of water to obtain a two-phase system; and recovering candesartan cilexetil.