ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	TEMPEST, Paul A, MASSE, Craig E, TOMLINSON, Susan Ann, ALBRECHT, Brian K, PARAS, Nick A, HODOUS, Brian L, WHITE, Ryan, THAMAN, Maya C, MCGOWAN, David C, PETTUS, Liping H, RZASA, Robert M, CHAFFEE, Stuart C, BUCKNER, William H, BUCHANAN, John L, HABGOOD, Gregory J, FALSEY, James Richard, DIMAURO, Erin F, BELLON, Steven, BEMIS, Jean E, CAO, Guo-giang, DEAK, Holly L, LIU, Gang, XU, Shimin, SMITH, Adrian Leonard, HERBERICH, Bradley J, CEE, Victor J, PATEL, Vinod F, ZHANG, Dawei, KIM, Joseph L, MARTIN, Matthew W, SHAM, Kelvin, GRACEFFA, Russell, TASKER, Andrew, REED, Anthony, HARMANGE, Jean-christophe, CHAKRABARTI, Partha P, DEMORIN, Frenel F, GEUNS-MEYER, Stephanie D, OLIVIERI, Philip R
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.