A self-inactivating recombinant lentiviral vector for the inhibition of HIV replication

A self-inactivating recombinant lentiviral vector for the inhibition of HIV replication

The present invention refers to a self-inactivating recombinant lentiviral vector comprising a 5' LTR and a 3' LTR, wherein the LTR region has been rendered substantially transcriptionally inactive by virtue of deletions in the U3 region of the 3' LTR, characterized in that the lentiv...

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Bibliographische Detailangaben
Hauptverfasser: PIETTE, JACQUES, RAVET, EMMANUEL, KHATISSIAN, EMMANUEL, BRULE-RAVET, FABIENNE
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
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Beschreibung
Zusammenfassung:The present invention refers to a self-inactivating recombinant lentiviral vector comprising a 5' LTR and a 3' LTR, wherein the LTR region has been rendered substantially transcriptionally inactive by virtue of deletions in the U3 region of the 3' LTR, characterized in that the lentiviral vector is further comprising a beta-interferon gene positioned under the control of a promoter.