PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS

PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS

The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is independently -N ; RP3 i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ROMAN VELA, ESTEBAN, GILL, ADRIAN L, SPRINGER, CAROLINE J, NICULESCU-DUVAZ, ION, TAYLOR, RICHARD D, MARAIS, RICHARD M
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is independently -N ; RP3 is independently a group of the formula -J1-L1-Z; -J1L1-Z is independently -NH-Z; Z is independently C6-14carboaryl and is independently unsubstituted or substituted; RP2 is independently -H; RP5 is independently a group of the formula -W-Y; W is independently -O-; Y is independently C6-14 carboaryl and is independently unsubstituted or substituted; and RP6 is independently -H. The present invention also pertains to pharmaceutical compositions comprising such compounds.