MODIFIED 5'- PHOSPHONATE AZIDOTHYMIDINE-POTENTIAL ANTI-VIRAL PREPARATIONS

The invention relates to the field of molecular biology, virology and medicine and, more specifically, to novel derivatives of 3'-azido-3'-deoxythymidine phosphonates with the following general formula where R = alkyl groups, including those containing halogen atoms, carboxy-, hydroxy-, al...

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Bibliographische Detailangaben
Hauptverfasser:	SHIROKOVA, ELENA ANATOLIEVNA, KHANDAJINSKAYA, ANASTASIYA, LVOVNA, POKROVSKY, ANDREY GEORGIEVICH, YASKO, MAXIM VLADIMIROVICH, SHIPITSYN, ALEXANDER V
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The invention relates to the field of molecular biology, virology and medicine and, more specifically, to novel derivatives of 3'-azido-3'-deoxythymidine phosphonates with the following general formula where R = alkyl groups, including those containing halogen atoms, carboxy-, hydroxy-, alkoxy- and acyloxy- groups as well as substituted aminocarbonyl groups. The compounds can be used as antiviral agents as they have low toxicity and can effectively inhibit replication of type 1 immunodeficiency virus in MT-4 cell culture and generate AZT in mammalians ensuring a gradual increase of its concentration in the blood.