USE OF CR1-BINDING MOLECULES IN CLEARANCE AND INDUCTION OF IMMUNE RESPONSES

USE OF CR1-BINDING MOLECULES IN CLEARANCE AND INDUCTION OF IMMUNE RESPONSES

The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effecting clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CASEY, LESLIE, S, JONES, STEVEN, MARION, MOHAMED, NEHAL, SPITALNY, GEORGE, L, PINCUS, STEVEN E
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effecting clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which binds specifically to complement receptor 1 (CR1) and does not substantially bind to complement receptor 2 (CR2), linked to a second moiety which comprises the antigen or binds to the antigen. Methods of producing such molecules and their therapeutic and/or prophylactic uses are also featured.