A NOVEL PROCESS FOR PURIFICATION OF HUMAN GROWTH HARMONE

Adding enough organic solvent to hydrophobic interactive chromatography elution buffer eliminates the need to also add detergent to the buffer when separating poly-peptides. For example, adding about 50% acetonitrile to detergent-free elution buffer enaibls one to separate full-length human growth h...

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Hauptverfasser:	BORBHUIYA, AHMED MONSUR, RAO, LAXMI SRINIVAS, MISHRA, SHRIKANT, NIPHADKAR, PRABHAKAR MILIND, MAITI, DIPANWITA, RAO, YADA MADHAVA
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Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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creator	BORBHUIYA, AHMED MONSUR RAO, LAXMI SRINIVAS MISHRA, SHRIKANT NIPHADKAR, PRABHAKAR MILIND MAITI, DIPANWITA RAO, YADA MADHAVA
description	Adding enough organic solvent to hydrophobic interactive chromatography elution buffer eliminates the need to also add detergent to the buffer when separating poly-peptides. For example, adding about 50% acetonitrile to detergent-free elution buffer enaibls one to separate full-length human growth hormone from its various truncated forms, to obtain hGH with a purity of >99.5%. This technique is useful to purify polypeptide where detergent to contamination in the resulting polypeptide is undesirable.
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subjects	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
title	A NOVEL PROCESS FOR PURIFICATION OF HUMAN GROWTH HARMONE
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