Extracts from hypericum L. species useful for the treatment of persistent tuberculosis

The present invention relates to extracts from species of the genus Hypericum L., namely H . humifusum L., H. calycinum L., H. elodes L ., H. hircinum subsp. majus (Aiton) N. Robson, H . glandulosum Aiton, H . grandifolium Choisy and H . foliosum Aiton, obtained by extraction with an hydroxylated so...

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Hauptverfasser: PRETO XAVIER LOBO MOUTINHO MEDEIROS, MARIA AUGUSTA, VIDAL DE OLIVEIRA BAPTISTA, LUNA-HERRERA, JULIETA, REYES RODRIGUEZ, ERIKA DEL CARMEN, DUARTE DIAS MENDES NOGUEIRA, MARIA TERESA, GONCALVES DA COSTA, MARIA DO CEU, MARTINS MOITEIRO, CRISTINA MARIA
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to extracts from species of the genus Hypericum L., namely H . humifusum L., H. calycinum L., H. elodes L ., H. hircinum subsp. majus (Aiton) N. Robson, H . glandulosum Aiton, H . grandifolium Choisy and H . foliosum Aiton, obtained by extraction with an hydroxylated solvent or mixtures with water in order to obtain, after solvent evaporation, concentrated extracts active against multidrug-resistant strains of Mycobacterium tuberculosis. The invention also relates to a method of preparation of the above extracts as well as to pharmaceutical compositions that contain these extracts, useful in the treatment and/or prevention of persistent tuberculosis.