HIV INHIBITING 1.2.4-TRIAZIN-6-ONE DERIVATES

The present invention relates to HIV replication inhibitors of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl; n and m are 1 to 4; R1 represents hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxyC1-6alkylcarbonyl substituted with C1-6alkyloxycarbonyl; R2 or R4 represents hydrogen; hydroxy; halo; optionally substituted C1-6alkyl; optionally substituted C2-6alkenyl; optionally substituted C2-6alkynyl; C3-7cycloalkyl; C1-6alkyloxy; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-4alkyl; polyhaloC1-4alkyloxy; polyhaloC1-4alkylthio; -S( O)pR6; -NH-S( O)pR6; -C( O)R6; -NHC( O)H; -C( O)NHNH2; NHC( O)R6; C( NH)R6; or R7; R2a or R3 represents cyano; aminocarbonyl; amino; halo; NHR13; NR13R14; -C( O)-NHR13; -C( O)-NR13R14; -C( O)-R15; -CH N-NH-C( O)-R16; optionally substituted C1-6alkyl; optionally substituted C1-6alkyloxy; optionally substituted C1-6alkyloxyC1-6alkyl; optionally substituted C2-6alkenyl; optionally substituted C2-6alkynyl; -C( N-O-R8)-C1-4alkyl; R7 or -X3-R7; X1 or X2 represents -NR1-; -NH-NH-; -N N-; -O-; -C( O)-; -C1-4alkanediyl-; -CHOH-; -S-; -S( O)p-; -X4-C1-4alkanediyl-; -C1-4alkanediyl-X4-; or -C1-4alkanediyl-X4-C1-4alkanediyl-; their use as a medicine, their use for the manufacture of a medicament for the treatment or the prevention of HIV infection; their processes for preparation and pharmaceutical compositions comprising them.