AN IMPROVED PROCESS FOR LACTONIZATION IN THE PREPARATION OF STATINS

The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing t...

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Bibliographische Detailangaben
Hauptverfasser:	THAPER, RAJESH, KUMAR, DUBEY, SUSHIL, KUMAR, BHADWAL, PARAMVIR, JAISWAL, SANJAY, KHANNA, JAG, MOHAN, PANCHASARA, DINESH, R, SINGH, GOVIND
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.