Device to stimulate therapeutic angiogenesis for ischemia and heart failure

The invention relates to a device for use in a body having a blood conduit, the device comprising: a first electrical output channel (202, 1202) configured to deliver a sub-threshold voltage below a threshold voltage required to cause a local depolarization of cardiac myocyte cell membranes; a liquid or solid treatment agent that stimulates angiogenesis; a first lead (206, 1206) comprising a proximal end.(208, 1208) configured to be electrically connected to the first electrical output channel (202, 1202), and a distal end (210, 1210) adapted to be placed in the blood conduit and configured to deliver said liquid or solid treatment agent; a cannula (215) including a lumen (212) configured to store or deliver the liquid or solid treatment agent, wherein the first lead is disposed within the lumen (212); and at least one electrode (214, 1214) disposed near the distal end (210, 1210) of the first lead (206, 1206).