3,4-DISUBSTITUTED MALEIMIDES FOR USE AS VASCULAR DAMAGING AGENTS

This invention relates to novel compounds of Formula (I) for use as vascular damaging agents: Formula (I) wherein R, R , R , R , AR , AR , AR , p, q and r are as described in the specification. The invention also relates to methods for preparing compounds of Formula (I), to their use as medicaments...

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Hauptverfasser: HARRIS, CRAIG STEVEN, BOYLE, FRANCIS THOMAS, GIBSON, KEITH, ARNOULD, JEAN-CLAUDE
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creator HARRIS, CRAIG STEVEN
BOYLE, FRANCIS THOMAS
GIBSON, KEITH
ARNOULD, JEAN-CLAUDE
description This invention relates to novel compounds of Formula (I) for use as vascular damaging agents: Formula (I) wherein R, R , R , R , AR , AR , AR , p, q and r are as described in the specification. The invention also relates to methods for preparing compounds of Formula (I), to their use as medicaments (including methods for the treatment of angiogenesis or disease states associated with angiogenesis) and to pharmaceutical compositions containing compounds of Formula (I).
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 3,4-DISUBSTITUTED MALEIMIDES FOR USE AS VASCULAR DAMAGING AGENTS
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