CRYSTALLINE POLYMORPHS OF A CXC-CHEMOKINE RECEPTOR LIGAND

The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed...

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Bibliographische Detailangaben
Hauptverfasser:	MCALLISTER, TIMOTHY, KIM-MEADE, AGNES, KLOPFER, KEVIN, HU, MENGWEI, YIN, JIANGUO, ZHANG, SHUYI, YU, YOUNONG, DWYER, MICHAEL, FU, XIAOYONG, TAVERAS, ARTHUR, G
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.