Fusion proteins comprising an angiostatin moiety and their use in anti-tumour treatment

The present invention relates to the development of novel multi-functional proteins (MFPs) of the formula: R 1 -L 1 -R 2 , R 2 -L 1 -R 1 , R 1 -L 1 -R 1 , R 1 -R 2 , R 2 -R 1 , or R 1 -R 1 where R 1 is angiostatin, R 2 is selected from endostatin, human type I interferon, thrombospondin, interferon-...

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Bibliographische Detailangaben
Hauptverfasser:	GREGORY, SUSAN A, KLEIN, BARBARA K, CAPARON, MAIRE H, CASPERSON, GERALD F, BOLANOWSKI, MARK A, MCKEARN, JOHN P
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the development of novel multi-functional proteins (MFPs) of the formula: R 1 -L 1 -R 2 , R 2 -L 1 -R 1 , R 1 -L 1 -R 1 , R 1 -R 2 , R 2 -R 1 , or R 1 -R 1 where R 1 is angiostatin, R 2 is selected from endostatin, human type I interferon, thrombospondin, interferon-inducible protein 10, platelet factor 4, and L 1 is a linker capable of linking R 1 to R 2 . The invention is also drawn to nucleic acids that encode MFPs, procedures for manufacturing MFPs, methods of using MFPs, methods of treating angiogenic-mediated disease with MFPs including methods of treating tumors with MFPs, and treating tumors by gene therapy using vectors that encode MFPs.