PYRIDO- AND PYRIMIDOPYRIMIDINE DERIVATIVES AS ANTI-PROLIFERATIVE AGENTS

The present invention concerns the compounds of formula wherein a1-a2=a3-a4 represents a divalent radical selected from N-CH CH-CH, N-CH N-CH or CH-CH N-CH; Z represents NH; Y represents -C3-9alkyl-, -C1-5alkyl-NR13-C1-5alkyl-, -C1-6 alkyl-NH-CO- or -CO-NH-C1-6alkyl-; X1 represents -O- or -NR11-; X2...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PONCELET, V.S, WILLEMS, MARC, STORCK, PIERRE H, FREYNE, EDDY JEAN E, VAN EMELEN, KRISTOF, EMBRECHTS, WERNER C.J, BUIJNSTERS, P.J.J.A, PERERA, TIMOTHY P.S
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention concerns the compounds of formula wherein a1-a2=a3-a4 represents a divalent radical selected from N-CH CH-CH, N-CH N-CH or CH-CH N-CH; Z represents NH; Y represents -C3-9alkyl-, -C1-5alkyl-NR13-C1-5alkyl-, -C1-6 alkyl-NH-CO- or -CO-NH-C1-6alkyl-; X1 represents -O- or -NR11-; X2 represents -C1-2alkyl-, -O-C1-2alkyl, -O- or -O-CH2-; R1 represents hydrogen or halo; R2 represents hydrogen, cyano, halo, hydroxycarbonyl-, C1-4alkyloxycarbonyl-, Het16-carbonyl- or Ar5; R3 represents hydrogen; R4 represents hydroxy, C1-4alkyloxy-, Ar4-C1-4alkyloxy or substituted C1-4alkyloxy; R11 represents hydrogen; R12 represents hydrogen, C1-4alkyl- or C1-4alkyl-oxy-carbonyl-; R13 represents morpholinyl-C1-4alkyl; Het2 represents morpholinyl or piperidinyl optionally substituted with C1-4alkyl-, preferably methyl; Het14 represents morpholinyl; Het16 represents morpholinyl or pyrrolidinyl; Ar4 represents phenyl; Ar5 represents phenyl optionally substituted with cyano.