COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS

COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS

Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying mol...

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Hauptverfasser: MAMO, SHUMEYE, HABETS, GASTON, BREMER, RYAN, KRUPKA, HEIKE, ARTIS, RICHARD, DEAN, ZUCKERMAN, REBECCA, NESPI, MARIKA, IBRAHIM, PRABHA, WEST, BRIAN, ZHU, YONG, ZHANG, JIAZHONG, KUMAR, ABHINAV, ZHANG, CHAO, HURT, CLARENCE, R
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.