VACCINE COMPOSITIONS WHICH ARE USED TO CONTROL AMOEBIASIS AND WHICH ARE BASED ON THE 112KDA SURFACE PROTEIN FROM ENTAMOEBA HISTOLYTICA

SUMMARY This invention relates to the field of immunology, specifically to vaccinal compositions for the control of infections caused by Entamoeba histolytica. The active principle of the compositions of the invention is a 112kDa amoebian surface protein, coded by two genes, one coding for a peptide...

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Bibliographische Detailangaben
Hauptverfasser:	MARTINEZ BENITEZ, MAXIMO B, ACOSTA DOMINGUEZ, ARMANDO, GARCIA RIVERA, G, GARCIA MADRIZ, XOCHIL, RODRIGUEZ RODRIGUEZ, MARIO A, OROZCO OROZCO, MARIA E, SIERRA GONZALEZ, GUSTAVO VICTORIANO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	SUMMARY This invention relates to the field of immunology, specifically to vaccinal compositions for the control of infections caused by Entamoeba histolytica. The active principle of the compositions of the invention is a 112kDa amoebian surface protein, coded by two genes, one coding for a peptide with cystein protease activity and the other for a peptide with adhesin activity. The scope of the invention includes formulations containing the genes coding for said protein, which are administered as DNA vaccines and also formulations containing the purified proteins or fragments thereof, achieving a synergic effect as regards protection with the combination. These formulations can be administered for prophylactic or therapeutical purposes to fight against the amoebian infection caused by the protozoan parasite Entamoeba histolytica.