6-ALKENYL AND 6-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS

The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.

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Bibliographische Detailangaben
Hauptverfasser: VAN DUN, Jacobus Alphonsus Josephus, SOMERS, Maria Victorina Francisca, GUILLEMONT, Jérôme Emile Georges, WOUTERS, Walter Boudewijn Leopold, MABIRE, Dominique Jean-Pierre
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.