NEW RAR-beta RECEPTOR-ACTIVATING LIGAND, METHOD FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS

6-(3-(1-Adamantyl)-4-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)phenyl)-2-naphthoic acid (I) and its salts and optical and geometric isomers are new. 6-(3-(1-Adamantyl)-4-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)phenyl)-2-naphthoic acid of formula (I) and its salts and optical and geometric isomers are ne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	COLLETTE, PASCAL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	6-(3-(1-Adamantyl)-4-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)phenyl)-2-naphthoic acid (I) and its salts and optical and geometric isomers are new. 6-(3-(1-Adamantyl)-4-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)phenyl)-2-naphthoic acid of formula (I) and its salts and optical and geometric isomers are new. [Image] An independent claim is also included for a pharmaceutical or cosmetic composition containing (I). ACTIVITY : Dermatological; Cytostatic; Immunosuppressive; Virucide; Ophthalmological; Antiseborrheic; Antiinflammatory; Vulnerary. MECHANISM OF ACTION : Retinoic acid receptor RARbeta agonist. (I) Had an apparent affinity constant (Kd) of 60 nM for RARbeta , 8000 nM for RARalpha and 4000 nM for RARgamma .