PROTEASOME INHIBITORS AND METHODS OF USING THE SAME

PROTEASOME INHIBITORS AND METHODS OF USING THE SAME

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorde...

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Bibliographische Detailangaben
Hauptverfasser: OLIVA, AMBROGIO, IQBAL, MOHAMED, BERNAREGGI, ALBERTO, D'ARASMO, GERMANO, CASSARA, PAOLO, G, FERRETTI, EDMONDO, DE NUNARI, SERGIO, CHATTERJEE, SANKAR, MESSINA MCLAUGHLIN, PATRICIA, A, BERNARDINI, RAFAELLA, MENTA, ERNESTO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.