Antibiotic drosocin derivatives

Antibiotic drosocin derivatives

The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable of replacing said amino acid. These derivatives can be used for...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAN BOOM, JACOBUS HUBERTUS, NOORT, DANIEL, OVERKLEEFT, HERMAN STEVEN, VAN HOOFT, PETRUS ALBERTUS VENANTIA, DE VISSER, PETER CHRISTIAN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable of replacing said amino acid. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition.