CYCLIC BIOISOSTERS OF PURINE SYSTEM DERIVATIVES AND A PHARMACEUTICAL COMPOSITION BASED THEREON

The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula R 1 = -H, -NH 2 , -Br, -C1, -OH, -COOH, B = -N=, -CH=, Z = -CH=, -N=, A = -N= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -N=, A = -CH= at B = -CH=, Z = -CH=, A = -CH= at B = -CH=, Z = -N= , and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.