Compounds and methods for assessment of Microsatellite Instability (MSI) status

The present invention provides a method for assessment of the Microsatellite Instability (MSI) status of medically relevant conditions associated with MSI phenotype such as e.g. neoplastic lesions. The method is based on the analysis of a monomorphic mononucleotide repeat located in the 3'-UTR...

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Bibliographische Detailangaben
Hauptverfasser: FINDEISEN, PETER, KLOOR, MATTHIAS, VON KNEBEL DOEBERITZ, MAGNUS, MERX, SABINE
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention provides a method for assessment of the Microsatellite Instability (MSI) status of medically relevant conditions associated with MSI phenotype such as e.g. neoplastic lesions. The method is based on the analysis of a monomorphic mononucleotide repeat located in the 3'-UTR of the Caspase 2 (CASP2) gene. Based on the determination of the length of the named mononucleotide repeat the presence or absence of MSI may be assessed. Determination of the length is p