Peptidic compounds and derivatives thereof for the treatment of human diseases through inhibition of signaling via growth factors

The present invention provides peptide derivatives designed to deliver growth factor receptor inhibitory activity. The invention relates to the use of such peptide drugs and derivatives thereof for the treatment of human diseases through the inhibition of growth factor receptor signaling, in particular involving signals mediated by hepatocyte growth factor (HGF), c-met and CD44. The invention comprises a use of compounds for the treatment and prevention of hyperproliferative disorders or diseases associated with an increased invasive potential of cells, such as cancer, including the treatment and prevention of tumor metastases and minimal residual disease. The invention includes the manufacture of a clinically used medicament for the treatment and prevention of human diseases associated with abberant gene expression patterns due to aberrant signaling via HGF.