DETECTION OF PROTEASE-RESISTANT PRION PROTEIN ACCORDING TO AN ASYMMETRIC SPONTANEOUS INTERACTION

DETECTION OF PROTEASE-RESISTANT PRION PROTEIN ACCORDING TO AN ASYMMETRIC SPONTANEOUS INTERACTION

The present invention concerns methods for detecting infectious prion protein with improved sensitivity. For this purpose the heterologous non-pathogenic protease-sensitive prion protein PrPc is added to a sample to be examined and is transformed into protease-resistant prion aggregates by asymmetri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: GASSNER, DIETER
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The present invention concerns methods for detecting infectious prion protein with improved sensitivity. For this purpose the heterologous non-pathogenic protease-sensitive prion protein PrPc is added to a sample to be examined and is transformed into protease-resistant prion aggregates by asymmetric spontaneous interaction when the infectious prion protein PrPSc is present in the sample.