ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS

This invention is directed to 3-((N-acylated aminoacyl)amino)pyrazoles of Formula (I). The invention is also directed to a pharmaceutical formulation comprising such compound or a pharmaceutically acceptable salt thereof. The invention is further directed to a method for inhibiting beta-amyloid pept...

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Bibliographische Detailangaben
Hauptverfasser:	WONE, DAVID, W., G, PLEISS, MICHAEL, A, TUCKER, JOHN, JENKINS, SCOTT, A, DRESSEN, DARREN, SEALY, JENNIFER, LATIMER, LEE, H, WU, JING, TUNG, JAY, S, GAROFALO, ALBERT, GUINN, ASHLEY, C
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This invention is directed to 3-((N-acylated aminoacyl)amino)pyrazoles of Formula (I). The invention is also directed to a pharmaceutical formulation comprising such compound or a pharmaceutically acceptable salt thereof. The invention is further directed to a method for inhibiting beta-amyloid peptide release and/or synthesis, a method for inhibiting gamma-secretase activity, and a method for treating neurological disorders associated with beta-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula (I). The compounds of Formula (I) are useful in the prevention and treatment of Alzheimer's disease.