BINDER COMPOSITION AND METHOD FOR PROCESSING POORLY COMPRESSIBLE DRUGS INTO TABLETS OF PREDETERMINED HARDNESS AND FRIABILITY

BINDER COMPOSITION AND METHOD FOR PROCESSING POORLY COMPRESSIBLE DRUGS INTO TABLETS OF PREDETERMINED HARDNESS AND FRIABILITY

Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or po...

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Bibliographische Detailangaben
Hauptverfasser: ETIENNE, SIDNEY, HALDAR, RAMA, DUBROWNY, GREG, DREFKO, WILLIAM, ZAMORA, JOHN, RAY, DIPAN, B
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10° C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.