BI-CYCLIC PYRIMIDINE INHIBITORS OF TGF BETA

BI-CYCLIC PYRIMIDINE INHIBITORS OF TGF BETA

Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGFbeta activity.

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Bibliographische Detailangaben
Hauptverfasser: MCENROE, GLENN, CHAKRAVARTY, SARVAJIT, DUGAR, SUNDEEP, AXON, JONATHAN, CONTE, AURELIA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGFbeta activity.