SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS

This invention relates to novel diaryl ureas of formula I wherein A is phenyl, naphthyl, mono- or bi-cyclic heteroaryl, or a group of the formula B is phenyl, naphthyl, or pyridyl, L is a bridging group Q is: (1) C(S)NR R ; (2) C(O)NR -NR R ; (3) tetrazolyl; (4) imidazolyl; (5) imidazoline-2-yl; (6)...

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Bibliographische Detailangaben
Hauptverfasser:	DUMAS, JACQUES, CHEN, JIANGING, CHEN, YUANWEI, ADNANE, LILA, CHEN, ZHI, LEE, WENDY, YI, LIN, VERMA, SHARAD, SCOTT, WILLIAM, J
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to novel diaryl ureas of formula I wherein A is phenyl, naphthyl, mono- or bi-cyclic heteroaryl, or a group of the formula B is phenyl, naphthyl, or pyridyl, L is a bridging group Q is: (1) C(S)NR R ; (2) C(O)NR -NR R ; (3) tetrazolyl; (4) imidazolyl; (5) imidazoline-2-yl; (6) 1,3,4-oxadiazoline-2-yl; (7) 1,3-thiazoline-2-yl; (8) 5-thioxo-4,5-dihydro-1,3,4-thiazoline-2-yl; (9) 5-oxo-4,5-dihydro-1,3,4-oxadiazoline-2-yl; or (10) a group of the formula and, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.